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Related post: LMSF, NIAID
COOPERATING UNITS (it any)
Z. Pei, Special Volunteer
K. Brown, Special Volunteer, Arthritis Foundation
V. Tolstikov. Contractor
LAB/BRANCH
Laboratory of Microbial Structure and Function
INSTITUTE AND LOCATION
NIAID, NIH, Bethesda, MD 20892
TOTAL STAFF YEARS:
4.25
PROFESSIONAL:
2.5
1.75
CHECK APPROPRIATE BOX{ES)
D (a) Human subjects
n (a1) Minors
D (a2) Interviews
Kl (b) Human tissues D (c) Neither
SUMMARY OF WORK (Use standard unreduced type. Do not exceed the space provided.)
The goal Toprol Xl Vs Metoprolol Tartrate of this work is to Toprol Xl Generic Name study the structure Toprol Xl Beta Blocker and function of the immunoglobulin
molecule. The work is being performed so that this Toprol Xl Generic Recall understanding will be applied
to the development of antibodies for human therapy.
A. Therapeutic systems. 1. Antibodies to surface antigens of group B streptococci
(GBS) have been Toprol Xl Vs Generic demonstrated to have protective efficacy in a model of neonatal
sepsis. We have identified colony opacity variants of GBS and studied their
interactions with antibodies and other components of the immune system. 2. The
efficacy of anti-HIV antibodies Is Toprol A Beta Blocker coupled to ricin A-chain has been studied in vitro.
Monoclonal and polyclonal antibodies directed against different epitopes have been
tested. Biological variants of HIV that escape killing with these immunotoxins and
CD4-PE40 have been Toprol Xl Generic Equivalent identified. The phenotype of the cells carrying these HIV has
been studied, and the molecular mechanisms of immunotoxin escape have been
evaluated. We have Cost Of Toprol Xl also constructed anti-MuLV immunotoxins, and the efficacy of
anti-retroviral immunotoxins is being tested in vivo in well-studied animal
systems .
B. Genetically engineered antibodies. Vectors have been prepared carrying human
constant region genes. These constructs Toprol Xl 50 Mg Recall contain both native and altered genes
These constructs have been ligated to variable region genes from antibodies to the
synthetic polypeptide (Tyr,Glu) -Ala--Lys . Antibodies were expressed and purified
The antigen-binding capability of these antibodies has been tested. Well-defined
immune complexes were constructed using antigens having different epitope
densities. The Metoprolol Vs Toprol Xl ability of the immune complexes to interact with the complement
system has being studied.
16-6
PflS 6040 (Hev. b/92)
DEPARTMENT OF HEALTH AND HUMAN SERVICES - PUBLIC Metoprolol Tartrate Vs Toprol Xl HEALTH SERVICE
NOTICE OF INTRAMURAL RESEARCH Is Toprol Xl A Beta Blocker PROJECT
PROJECT NUMBER
ZOl AI 00549-04
PERIOD COVERED
October 1, 1991, to September 30, 1992
TITLE OF PROJECT (BO characters or less. Title must lit on one line between the borders.)
Pathogenesis of Infection with the Lyme Disease Spirochete, Barrel ia burgdorferi
PRINCIPAL INVESTIGATOR (List other prolesskxial personnel bekm Generic For Toprol Xl the Principal Investigator.) (Name, title, laboratory, and institute affiliation)
P.I.: P. A. Rosa Senior Staff Fellovi? LMSF, NIAID
Others: K. L. Tilly Senior Staff Fellow LMSF, NIAID
D. M. Hogan Microbiologist LMSF, NIAID
COOPERATING UNITS (if any)
N. Margolis, Special Volunteer, Arthritis Foundation
J. Campbell, Stay In School Program
A. Sadziene and A. Barbour. University of Texas at San Antonio
LASmRANCH
Laboratory of Microbial Structure and Function
INSTITUTE AND LOCATION
NIAID, NIH, Bethesda, MD 20892
TOTAL Generic Name For Toprol Xl STAFF YEARS:
PROFESSIONAL:
CHECK APPROPRIATE BOX(ES)
D (a) Human subjects D (b) Human tissues E (c) Neither
D (a1) Toprol Generic Equivalent Minors
□ (a2) Interviews
SUMMARY OF WORK (Use standard unreduced type. Do not exceed the space provided.)
Infection of humans by Toprol Xl 100 Mg Borrelia burgdorferi (Bb) can result in a multisystemic,
chronic disease with Toprol Xl Coupons diverse manifestations. We are investigating B. burgdorferi
at several levels in order to understand some aspects of the disease pathogenesis.
These studies include genetic manipulations of the spirochete and characterization
of key structural and regulatory elements
1. Molecular Characterization: Several features of Bb are being addressed. We
have characterized homologous recombination between the genes encoding the major
outer surface proteins (Osps) that both deletes osp gene sequences and creates
chimeric Generic Name For Toprol Toprol Xl Coupon gene fusions. Bb expressing recombinant osp genes can "escape" killing by
Osp-specific neutralizing antibodies. We are also investigating mechanisms of
transcriptional regulation of osp gene expression. Isolating and studying genes
whose expression is increased after a temperature upshift (heat shock genes) will
provide information about their roles in cell growth, pathogenesis, plasmid
replication and adaptation to stress. Understanding the mechanism of linear
plasmid replication may yield a new target for antibiotics, in addition to shedding
light on ways in which organisms manipulate their genetic material
2. Gene Transfer: Toprol Xl Vs Metoprolol In order to allow genetic analysis of Bb, a method for gene
transfer into Borrelia is being developed. A derivative of the Bb 16 kb linear
plasmid will be used as a vector for electroporation, allowing for maintenance of
transferred DNA in a native setting. DNA encoding recombinant Osp proteins that
lack neutralizing epitopes will be introduced as a selectable marker
3. cDNA Library: Extended passage of Bb in vitro eliminates its ability to infect
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